Crossref journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract

Previous studies have indicated that human transcription initiation factor TFIID is a large complex that contains a TATA-binding polypeptide (TFIID tau or TBP) and other components that qualitatively alter promoter interactions and are uniquely required for activator-dependent (versus basal) transcription. TFIID tau-specific antibody columns have been employed to identify a number of human TFIID polypeptides that are tightly associated with TFIID tau. These differ in size from polypeptides in known general initiation factors, including the initiator-binding factor (TFII-I) which shares some promoter binding characteristics with TFIID. The largest component (p250) identified in TFIID was shown to interact directly and tightly with TFIID tau, suggesting that it may play a major role in the assembly of the TFIID complex.

Bibliography

Takada, R., Nakatani, Y., Hoffmann, A., Kokubo, T., Hasegawa, S., Roeder, R. G., & Horikoshi, M. (1992). Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau). Proceedings of the National Academy of Sciences, 89(24), 11809–11813.

Authors 7
  1. R Takada (first)
  2. Y Nakatani (additional)
  3. A Hoffmann (additional)
  4. T Kokubo (additional)
  5. S Hasegawa (additional)
  6. R G Roeder (additional)
  7. M Horikoshi (additional)
References 0 Referenced 43

None

Dates
Type When
Created 19 years, 2 months ago (May 31, 2006, 8:14 a.m.)
Deposited 3 years, 4 months ago (April 13, 2022, 1:33 p.m.)
Indexed 1 year, 7 months ago (Jan. 15, 2024, 6:25 a.m.)
Issued 32 years, 8 months ago (Dec. 15, 1992)
Published 32 years, 8 months ago (Dec. 15, 1992)
Published Online 32 years, 8 months ago (Dec. 15, 1992)
Published Print 32 years, 8 months ago (Dec. 15, 1992)
Funders 0

None

@article{Takada_1992, title={Identification of human TFIID components and direct interaction between a 250-kDa polypeptide and the TATA box-binding protein (TFIID tau).}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.24.11809}, DOI={10.1073/pnas.89.24.11809}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Takada, R and Nakatani, Y and Hoffmann, A and Kokubo, T and Hasegawa, S and Roeder, R G and Horikoshi, M}, year={1992}, month=dec, pages={11809–11813} }