DOI: 10.1073/pnas.89.21.10056. Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo.

Retinoic acid is enriched in Hensen's node and is developmentally regulated in the early chicken embryo.

10.1073/pnas.89.21.10056

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Retinoic acid (RA) has been considered as a potential morphogen in the chicken limb and has also been suggested to be involved in early embryonic development. On the basis of biological activity, previous reports suggest that Hensen's node, the anatomical equivalent in the chicken of the Spemann's organizer, may contain RA. Here, by using a molecular assay system, we demonstrate that Hensen's node contains retinoids in a concentration approximately 20 times more than that in the neighboring tissues. Furthermore, stage 6 Hensen's node contains approximately 3 times more retinoid than that of stage 4 embryos. These endogenous retinoids may establish a concentration gradient from Hensen's node to adjacent tissues and play a role in establishing the primary embryonic axis in the vertebrate. The results also suggest that the retinoid concentration in Hensen's node is developmentally regulated.

Bibliography

Chen, Y., Huang, L., Russo, A. F., & Solursh, M. (1992). Retinoic acid is enriched in Hensenâs node and is developmentally regulated in the early chicken embryo. Proceedings of the National Academy of Sciences, 89(21), 10056â10059.

Authors 4

Y Chen (first)
L Huang (additional)
A F Russo (additional)
M Solursh (additional)

References 0 Referenced 101

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:11 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:49 p.m.)
Indexed	3 months, 3 weeks ago (May 3, 2025, 5:22 p.m.)
Issued	32 years, 9 months ago (Nov. 1, 1992)
Published	32 years, 9 months ago (Nov. 1, 1992)
Published Online	32 years, 9 months ago (Nov. 1, 1992)
Published Print	32 years, 9 months ago (Nov. 1, 1992)

Funders 0

None

BibTeX

@article{Chen_1992, title={Retinoic acid is enriched in Hensen’s node and is developmentally regulated in the early chicken embryo.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.21.10056}, DOI={10.1073/pnas.89.21.10056}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Chen, Y and Huang, L and Russo, A F and Solursh, M}, year={1992}, month=nov, pages={10056–10059} }

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