DOI: 10.1073/pnas.89.2.499. Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.

Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.

10.1073/pnas.89.2.499

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A mouse cDNA encoding a non-receptor-type phosphotyrosine phosphatase (PTP; EC 3.1.3.48) has been isolated. The 1570-base-pair cDNA contains a single open reading frame that predicts a 382-amino acid protein with Mr 44,640. The nucleic acid and amino acid sequences are homologous to those of a previously described human T-cell PTP [Cool, D. E., Tonks, N. K., Charbonneau, H., Walsh, K. A., Fischer, E. H. & Krebs, E. G. (1989) Proc. Natl. Acad. Sci. USA 86, 5257-5261]; however, the mouse and human 3' sequences diverge and predict markedly different protein carboxyl termini. The mouse PTP gene is expressed as a 1.9-kilobase message in several stages of murine embryonic development and in a variety of adult tissues. An additional 1.3-kilobase message was found to be expressed specifically in testes. Finally, we report the isolation of a human T-cell PTP cDNA containing a 3' end sequence homologous to the mouse PTP.

Bibliography

Mosinger, B., Tillmann, U., Westphal, H., & Tremblay, M. L. (1992). Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences, 89(2), 499â503.

Authors 4

B Mosinger (first)
U Tillmann (additional)
H Westphal (additional)
M L Tremblay (additional)

References 0 Referenced 85

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:10 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:29 p.m.)
Indexed	1 month ago (July 30, 2025, 8:25 p.m.)
Issued	33 years, 7 months ago (Jan. 15, 1992)
Published	33 years, 7 months ago (Jan. 15, 1992)
Published Online	33 years, 7 months ago (Jan. 15, 1992)
Published Print	33 years, 7 months ago (Jan. 15, 1992)

Funders 0

None

BibTeX

@article{Mosinger_1992, title={Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.2.499}, DOI={10.1073/pnas.89.2.499}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Mosinger, B and Tillmann, U and Westphal, H and Tremblay, M L}, year={1992}, month=jan, pages={499–503} }

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