DOI: 10.1073/pnas.89.17.8140. Composition of transcription factor B-TFIID.

Composition of transcription factor B-TFIID.

10.1073/pnas.89.17.8140

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Initiation of transcription by RNA polymerase II requires a TFIID factor, which can recognize the TATA element common to many promoters. Two distinct multisubunit TFIID factors can be resolved from extracts of mammalian cells, and both of them contain the well-characterized TATA-binding protein (TBP) and are capable of supporting RNA polymerase II transcription in an in vitro reaction system. The smaller complex, B-TFIID, was purified and its subunit composition was determined. B-TFIID consists of two subunits: the TBP and a TBP-associated factor (TAF) of 170 kDa. This TAF is specific for B-TFIID and appears not to be present in the D-TFIID complex. Furthermore, it was found that the highly purified B-TFIID fractions have (d)ATPase activity.

Bibliography

Timmers, H. T., Meyers, R. E., & Sharp, P. A. (1992). Composition of transcription factor B-TFIID. Proceedings of the National Academy of Sciences, 89(17), 8140â8144.

Authors 3

H T Timmers (first)
R E Meyers (additional)
P A Sharp (additional)

References 0 Referenced 50

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:06 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:07 p.m.)
Indexed	5 months ago (March 30, 2025, 8:34 p.m.)
Issued	33 years ago (Sept. 1, 1992)
Published	33 years ago (Sept. 1, 1992)
Published Online	33 years ago (Sept. 1, 1992)
Published Print	33 years ago (Sept. 1, 1992)

Funders 0

None

BibTeX

@article{Timmers_1992, title={Composition of transcription factor B-TFIID.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.17.8140}, DOI={10.1073/pnas.89.17.8140}, number={17}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Timmers, H T and Meyers, R E and Sharp, P A}, year={1992}, month=sep, pages={8140–8144} }

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