DOI: 10.1073/pnas.89.16.7408. Serine tRNA complementary to the nonuniversal serine codon CUG in Candida cylindracea: evolutionary implications.

Serine tRNA complementary to the nonuniversal serine codon CUG in Candida cylindracea: evolutionary implications.

10.1073/pnas.89.16.7408

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In the asporogenic yeast Candida cylindracea, the codon CUG is read as serine instead of leucine. This is an unusual instance in which the amino acid assignment of a codon deviates from the universal code. To infer the evolutionary process of this change, the tRNA with the anticodon sequence CAG, which is complementary to and thus responsible for translation of the codon CUG, has been identified. Indeed, this tRNA translates an in-frame CUG codon in a synthetic mRNA as serine in an in vitro translation system. The gene for the tRNA is interrupted by an intron in the anticodon loop. Sequence comparisons of the tRNA and its gene suggest that a single cytidine was inserted into the anticodon loop of the gene for tRNA(Ser)IGA during evolution to produce tRNA(Ser)CAG. The tRNA(Ser)CAG may be produced from its precursor molecule containing the cytidine insertion by splicing.

Bibliography

Yokogawa, T., Suzuki, T., Ueda, T., Mori, M., Ohama, T., Kuchino, Y., Yoshinari, S., Motoki, I., Nishikawa, K., & Osawa, S. (1992). Serine tRNA complementary to the nonuniversal serine codon CUG in Candida cylindracea: evolutionary implications. Proceedings of the National Academy of Sciences, 89(16), 7408â7411.

Authors 10

T Yokogawa (first)
T Suzuki (additional)
T Ueda (additional)
M Mori (additional)
T Ohama (additional)
Y Kuchino (additional)
S Yoshinari (additional)
I Motoki (additional)
K Nishikawa (additional)
S Osawa (additional)

References 0 Referenced 45

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:05 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:02 p.m.)
Indexed	11 months, 1 week ago (Sept. 14, 2024, 6:39 a.m.)
Issued	33 years ago (Aug. 15, 1992)
Published	33 years ago (Aug. 15, 1992)
Published Online	33 years ago (Aug. 15, 1992)
Published Print	33 years ago (Aug. 15, 1992)

Funders 0

None

BibTeX

@article{Yokogawa_1992, title={Serine tRNA complementary to the nonuniversal serine codon CUG in Candida cylindracea: evolutionary implications.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.16.7408}, DOI={10.1073/pnas.89.16.7408}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Yokogawa, T and Suzuki, T and Ueda, T and Mori, M and Ohama, T and Kuchino, Y and Yoshinari, S and Motoki, I and Nishikawa, K and Osawa, S}, year={1992}, month=aug, pages={7408–7411} }

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