DOI: 10.1073/pnas.89.15.7129. A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

10.1073/pnas.89.15.7129

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Retinoic acid (RA) exerts its pleiotropic effects on cell growth and differentiation through the activation of a family of transcription factors-the RA receptors (RARs). Three subtypes of these receptors exist, RAR alpha, RAR beta, and RAR gamma. The receptors are differentially expressed in different cell types and stages of development, suggesting that they may regulate different sets of genes. We have identified a synthetic retinoid with the characteristics of a selective RAR alpha antagonist. This antagonist counteracts RA effects on HL-60 cell differentiation and on B-lymphocyte polyclonal activation. Beyond its potential practical relevance, this and other specific antagonists will be useful to dissect the RAR system and to assign to one given receptor each of the many RA-regulated functions.

Bibliography

Apfel, C., Bauer, F., Crettaz, M., Forni, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W., & Klaus, M. (1992). A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proceedings of the National Academy of Sciences, 89(15), 7129â7133.

Authors 9

C Apfel (first)
F Bauer (additional)
M Crettaz (additional)
L Forni (additional)
M Kamber (additional)
F Kaufmann (additional)
P LeMotte (additional)
W Pirson (additional)
M Klaus (additional)

References 0 Referenced 206

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:05 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:05 p.m.)
Indexed	3 weeks, 2 days ago (Aug. 3, 2025, 7 p.m.)
Issued	33 years ago (Aug. 1, 1992)
Published	33 years ago (Aug. 1, 1992)
Published Online	33 years ago (Aug. 1, 1992)
Published Print	33 years ago (Aug. 1, 1992)

Funders 0

None

BibTeX

@article{Apfel_1992, title={A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.15.7129}, DOI={10.1073/pnas.89.15.7129}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Apfel, C and Bauer, F and Crettaz, M and Forni, L and Kamber, M and Kaufmann, F and LeMotte, P and Pirson, W and Klaus, M}, year={1992}, month=aug, pages={7129–7133} }

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