DOI: 10.1073/pnas.89.11.4928. Proteasomes are regulated by interferon gamma: implications for antigen processing.

Proteasomes are regulated by interferon gamma: implications for antigen processing.

10.1073/pnas.89.11.4928

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Class I major histocompatibility complex (MHC) molecules present antigenic peptides of cytoplasmic origin to T cells. As the lengths of these peptides seem restricted to eight or nine amino acids, an unusual proteolytic system must play a role in antigen processing. Proteasomes, a major extralysosomal proteolytic system, are responsible for the degradation of cytoplasmic proteins. We demonstrate that several proteasomal subunits, including MHC-encoded subunits, are regulated by interferon gamma. These data and the finding that MHC-encoded and other interferon gamma-regulated proteasomal subunits are uniquely associated with proteasomes strongly suggest that the immune system has recruited proteasomes for antigen processing.

Bibliography

Yang, Y., Waters, J. B., FrÃ¼h, K., & Peterson, P. A. (1992). Proteasomes are regulated by interferon gamma: implications for antigen processing. Proceedings of the National Academy of Sciences, 89(11), 4928â4932.

Authors 4

Y Yang (first)
J B Waters (additional)
K Früh (additional)
P A Peterson (additional)

References 0 Referenced 124

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 8:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:12 p.m.)
Indexed	1 month, 2 weeks ago (July 8, 2025, 4:25 a.m.)
Issued	33 years, 2 months ago (June 1, 1992)
Published	33 years, 2 months ago (June 1, 1992)
Published Online	33 years, 2 months ago (June 1, 1992)
Published Print	33 years, 2 months ago (June 1, 1992)

Funders 0

None

BibTeX

@article{Yang_1992, title={Proteasomes are regulated by interferon gamma: implications for antigen processing.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.11.4928}, DOI={10.1073/pnas.89.11.4928}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Yang, Y and Waters, J B and Früh, K and Peterson, P A}, year={1992}, month=jun, pages={4928–4932} }

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