DOI: 10.1073/pnas.89.11.4918. Optimal protein-folding codes from spin-glass theory.

Optimal protein-folding codes from spin-glass theory.

10.1073/pnas.89.11.4918

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Protein-folding codes embodied in sequence-dependent energy functions can be optimized using spin-glass theory. Optimal folding codes for associative-memory Hamiltonians based on aligned sequences are deduced. A screening method based on these codes correctly recognizes protein structures in the "twilight zone" of sequence identity in the overwhelming majority of cases. Simulated annealing for the optimally encoded Hamiltonian generally leads to qualitatively correct structures.

Bibliography

Goldstein, R. A., Luthey-Schulten, Z. A., & Wolynes, P. G. (1992). Optimal protein-folding codes from spin-glass theory. Proceedings of the National Academy of Sciences, 89(11), 4918â4922.

Authors 3

R A Goldstein (first)
Z A Luthey-Schulten (additional)
P G Wolynes (additional)

References 0 Referenced 290

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:13 p.m.)
Indexed	1 day, 7 hours ago (Aug. 30, 2025, 12:26 p.m.)
Issued	33 years, 2 months ago (June 1, 1992)
Published	33 years, 2 months ago (June 1, 1992)
Published Online	33 years, 2 months ago (June 1, 1992)
Published Print	33 years, 2 months ago (June 1, 1992)

Funders 0

None

BibTeX

@article{Goldstein_1992, title={Optimal protein-folding codes from spin-glass theory.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.11.4918}, DOI={10.1073/pnas.89.11.4918}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Goldstein, R A and Luthey-Schulten, Z A and Wolynes, P G}, year={1992}, month=jun, pages={4918–4922} }

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