DOI: 10.1073/pnas.89.11.4840. Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

10.1073/pnas.89.11.4840

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]. PML-RAR alpha is expressed as a fusion protein. We investigated the organization and expression pattern of the RAR alpha-PML gene in a series of APL patients representative of the molecular heterogeneity of the t(15;17) and found (i) two types of RAR alpha-PML mRNA junctions (RAR alpha exon 2/PML exon 4 or RAR alpha exon 2/PML exon 7) that maintain the RAR alpha and PML longest open reading frames aligned and are the result of chromosome 15 breaking at two different sites; and (ii) 10 different RAR alpha-PML fusion transcripts that differ for the assembly of their PML coding exons. A RAR alpha-PML transcript was present in most, but not all, APL patients.

Bibliography

Alcalay, M., Zangrilli, D., Fagioli, M., Pandolfi, P. P., Mencarelli, A., Lo Coco, F., Biondi, A., Grignani, F., & Pelicci, P. G. (1992). Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia. Proceedings of the National Academy of Sciences, 89(11), 4840â4844.

Authors 9

M Alcalay (first)
D Zangrilli (additional)
M Fagioli (additional)
P P Pandolfi (additional)
A Mencarelli (additional)
F Lo Coco (additional)
A Biondi (additional)
F Grignani (additional)
P G Pelicci (additional)

References 0 Referenced 111

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:13 p.m.)
Indexed	4 weeks ago (Aug. 3, 2025, 7:03 p.m.)
Issued	33 years, 3 months ago (June 1, 1992)
Published	33 years, 3 months ago (June 1, 1992)
Published Online	33 years, 3 months ago (June 1, 1992)
Published Print	33 years, 3 months ago (June 1, 1992)

Funders 0

None

BibTeX

@article{Alcalay_1992, title={Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.11.4840}, DOI={10.1073/pnas.89.11.4840}, number={11}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Alcalay, M and Zangrilli, D and Fagioli, M and Pandolfi, P P and Mencarelli, A and Lo Coco, F and Biondi, A and Grignani, F and Pelicci, P G}, year={1992}, month=jun, pages={4840–4844} }

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