DOI: 10.1073/pnas.89.10.4265. Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.

10.1073/pnas.89.10.4265

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned from a mouse placenta cDNA library. All three display strong homology in membrane-spanning domains M7 and M8 to the originally cloned cerebellar IP3R-I, with divergences predominantly in cytoplasmic domains. Levels of mRNA for the three additional IP3Rs in general are substantially lower than for IP3R-I, though in the gastrointestinal tract the levels of IP3R-III may be comparable to IP3R-I. Cerebellar Purkinje cells express at least two and possibly three distinct IP3Rs, suggesting heterogeneity of IP3 action within a single cell.

Bibliography

Ross, C. A., Danoff, S. K., Schell, M. J., Snyder, S. H., & Ullrich, A. (1992). Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues. Proceedings of the National Academy of Sciences, 89(10), 4265â4269.

Authors 5

C A Ross (first)
S K Danoff (additional)
M J Schell (additional)
S H Snyder (additional)
A Ullrich (additional)

References 0 Referenced 155

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 8:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:18 p.m.)
Indexed	5 months ago (March 30, 2025, 3:03 p.m.)
Issued	33 years, 3 months ago (May 15, 1992)
Published	33 years, 3 months ago (May 15, 1992)
Published Online	33 years, 3 months ago (May 15, 1992)
Published Print	33 years, 3 months ago (May 15, 1992)

Funders 0

None

BibTeX

@article{Ross_1992, title={Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.}, volume={89}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.89.10.4265}, DOI={10.1073/pnas.89.10.4265}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ross, C A and Danoff, S K and Schell, M J and Snyder, S H and Ullrich, A}, year={1992}, month=may, pages={4265–4269} }

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