DOI: 10.1073/pnas.88.24.11197. Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.

Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.

10.1073/pnas.88.24.11197

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The catalytic subunit (Mr approximately 124,000) of human DNA polymerase delta has been cloned by PCR using poly(A)+ RNA from HepG2 cells and primers designed from the amino acid sequence of regions highly conserved between bovine and yeast DNA polymerase delta. The human cDNA was 3443 nucleotides in length and coded for a polypeptide of 1107 amino acids. The enzyme was 94% identical to bovine DNA polymerase delta and contained the numerous highly conserved regions previously observed in the bovine and yeast enzymes. The human enzyme also contained two putative zinc-finger domains in the carboxyl end of the molecule, as well as a putative nuclear localization signal at the amino-terminal end. The gene coding for human DNA polymerase delta was localized to chromosome 19.

Bibliography

Chung, D. W., Zhang, J. A., Tan, C. K., Davie, E. W., So, A. G., & Downey, K. M. (1991). Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene. Proceedings of the National Academy of Sciences, 88(24), 11197â11201.

Authors 6

D W Chung (first)
J A Zhang (additional)
C K Tan (additional)
E W Davie (additional)
A G So (additional)
K M Downey (additional)

References 0 Referenced 44

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:52 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:25 p.m.)
Indexed	1 year ago (Sept. 3, 2024, 10:40 p.m.)
Issued	33 years, 8 months ago (Dec. 15, 1991)
Published	33 years, 8 months ago (Dec. 15, 1991)
Published Online	33 years, 8 months ago (Dec. 15, 1991)
Published Print	33 years, 8 months ago (Dec. 15, 1991)

Funders 0

None

BibTeX

@article{Chung_1991, title={Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.}, volume={88}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.88.24.11197}, DOI={10.1073/pnas.88.24.11197}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Chung, D W and Zhang, J A and Tan, C K and Davie, E W and So, A G and Downey, K M}, year={1991}, month=dec, pages={11197–11201} }

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