DOI: 10.1073/pnas.88.19.8582. Characterization of a neu/c-erbB-2 protein-specific activating factor. [Penn]

Characterization of a neu/c-erbB-2 protein-specific activating factor.

10.1073/pnas.88.19.8582

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The neu oncogene encodes a tyrosine kinase with growth factor receptor-like properties. A neu protein-specific activating factor (NAF) was partially purified from medium conditioned by the transformed human T-cell line ATL-2. NAF was able to stimulate the tyrosine-specific kinase activity of the neu protein (p185neu), induce dimerization and internalization, and increase the growth of cells bearing the neu protein. The effects of NAF were mediated by an interaction with the p185neu extracellular domain. NAF had no effect on the epidermal growth factor receptor kinase activity and no effect on cells that express that receptor. Further analysis of NAF and of other recently described neu protein-activating activities should help clarify the role of the neu protein in cell growth and transformation.

Bibliography

Dobashi, K., Davis, J. G., Mikami, Y., Freeman, J. K., Hamuro, J., & Greene, M. I. (1991). Characterization of a neu/c-erbB-2 protein-specific activating factor. Proceedings of the National Academy of Sciences, 88(19), 8582â8586.

Authors 6

K Dobashi (first)
J G Davis (additional)
Y Mikami (additional)
J K Freeman (additional)
J Hamuro (additional)
M I Greene (additional)

References 0 Referenced 36

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:47 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:23 p.m.)
Indexed	1 year, 6 months ago (Feb. 27, 2024, 12:23 a.m.)
Issued	33 years, 11 months ago (Oct. 1, 1991)
Published	33 years, 11 months ago (Oct. 1, 1991)
Published Online	33 years, 11 months ago (Oct. 1, 1991)
Published Print	33 years, 11 months ago (Oct. 1, 1991)

Funders 0

None

BibTeX

@article{Dobashi_1991, title={Characterization of a neu/c-erbB-2 protein-specific activating factor.}, volume={88}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.88.19.8582}, DOI={10.1073/pnas.88.19.8582}, number={19}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Dobashi, K and Davis, J G and Mikami, Y and Freeman, J K and Hamuro, J and Greene, M I}, year={1991}, month=oct, pages={8582–8586} }

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