DOI: 10.1073/pnas.87.9.3324. Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA.

Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA.

10.1073/pnas.87.9.3324

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Cancer treatment with the drug cisplatin is often thwarted by the emergence of drug-resistant cells. To study this phenomenon, we identified two independent cellular factors that recognize cisplatin-damaged DNA. One of the two factors, designated XPE binding factor, is deficient in complementation group E of xeroderma pigmentosum, an inherited disease characterized by defective repair of DNA damaged by ultraviolet radiation, cisplatin, and other agents. Human tumor cell lines selected for resistance to cisplatin showed more efficient DNA repair and increased expression of XPE binding factor. These results suggest that XPE binding factor may be responsible, at least in part, for the development of cisplatin resistance in human tumors and that the mechanism may be increased DNA repair.

Bibliography

Chu, G., & Chang, E. (1990). Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA. Proceedings of the National Academy of Sciences, 87(9), 3324â3327.

Authors 2

G Chu (first)
E Chang (additional)

References 0 Referenced 81

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:38 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:04 p.m.)
Indexed	1 month, 3 weeks ago (July 14, 2025, 11:46 p.m.)
Issued	35 years, 4 months ago (May 1, 1990)
Published	35 years, 4 months ago (May 1, 1990)
Published Online	35 years, 4 months ago (May 1, 1990)
Published Print	35 years, 4 months ago (May 1, 1990)

Funders 0

None

BibTeX

@article{Chu_1990, title={Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA.}, volume={87}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.87.9.3324}, DOI={10.1073/pnas.87.9.3324}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Chu, G and Chang, E}, year={1990}, month=may, pages={3324–3327} }

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