DOI: 10.1073/pnas.87.3.1008. Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin.

Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin.

10.1073/pnas.87.3.1008

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

From a group of 436 Drosophila melanogaster cDNA clones, we selected 39 that are expressed exclusively or predominantly in the adult visual system. By sequence analysis, 20 of the clones appear to represent previously unreported distinct cDNAs. The corresponding transcripts are detected in the retina and optic lobes. The genes are scattered throughout the genome, some near mutations known to affect eye function. One of these clones has been identified, by sequence analysis, as the structural gene (Arr) for a Drosophila homolog of human arrestin. Vertebrate arrestin interacts with rhodopsin in phototransduction and has been associated with an autoimmune form of uveitis in primates. The presence of an arrestin homolog in Drosophila suggests that both the vertebrate and invertebrate phototransduction cascades are regulated in a similar manner.

Bibliography

Hyde, D. R., Mecklenburg, K. L., Pollock, J. A., Vihtelic, T. S., & Benzer, S. (1990). Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin. Proceedings of the National Academy of Sciences, 87(3), 1008â1012.

Authors 5

D R Hyde (first)
K L Mecklenburg (additional)
J A Pollock (additional)
T S Vihtelic (additional)
S Benzer (additional)

References 0 Referenced 83

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 7:33 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:09 p.m.)
Indexed	1 week ago (Aug. 23, 2025, 1:02 a.m.)
Issued	35 years, 6 months ago (Feb. 1, 1990)
Published	35 years, 6 months ago (Feb. 1, 1990)
Published Online	35 years, 6 months ago (Feb. 1, 1990)
Published Print	35 years, 6 months ago (Feb. 1, 1990)

Funders 0

None

BibTeX

@article{Hyde_1990, title={Twenty Drosophila visual system cDNA clones: one is a homolog of human arrestin.}, volume={87}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.87.3.1008}, DOI={10.1073/pnas.87.3.1008}, number={3}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hyde, D R and Mecklenburg, K L and Pollock, J A and Vihtelic, T S and Benzer, S}, year={1990}, month=feb, pages={1008–1012} }

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