DOI: 10.1073/pnas.87.21.8467. Architecture of ribosomal RNA: constraints on the sequence of "tetra-loops".

Architecture of ribosomal RNA: constraints on the sequence of "tetra-loops".

10.1073/pnas.87.21.8467

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The four-base loops that cap many double-helical structures in rRNA (the so-called "tetra-loops") exhibit highly invariant to highly variable sequences depending upon their location in the molecule. However, in the vast majority of these cases the sequence of a tetra-loop is independent of its location and conforms to one of three general motifs, GNRA, UNCG, and (more rarely) CUUG. For the most frequently varying of the 16S rRNA tetra-loops, that at position 83 (Escherichia coli numbering), the three sequences CUUG, UUCG, and GCAA account for almost all examples encountered, and each of them has independently arisen at least a dozen times. The closing base pair of tetra-loop hairpins reflects the loop sequence, tending to be C.G for UUCG loops and G.C for CUUG loops.

Bibliography

Woese, C. R., Winker, S., & Gutell, R. R. (1990). Architecture of ribosomal RNA: constraints on the sequence of âtetra-loopsâ. Proceedings of the National Academy of Sciences, 87(21), 8467â8471.

Authors 3

C R Woese (first)
S Winker (additional)
R R Gutell (additional)

References 0 Referenced 372

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:30 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:15 p.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:56 a.m.)
Issued	34 years, 10 months ago (Nov. 1, 1990)
Published	34 years, 10 months ago (Nov. 1, 1990)
Published Online	34 years, 10 months ago (Nov. 1, 1990)
Published Print	34 years, 10 months ago (Nov. 1, 1990)

Funders 0

None

BibTeX

@article{Woese_1990, title={Architecture of ribosomal RNA: constraints on the sequence of “tetra-loops”.}, volume={87}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.87.21.8467}, DOI={10.1073/pnas.87.21.8467}, number={21}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Woese, C R and Winker, S and Gutell, R R}, year={1990}, month=nov, pages={8467–8471} }

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