DOI: 10.1073/pnas.87.19.7517. Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

10.1073/pnas.87.19.7517

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

T lymphocytes recognize endogenously produced antigenic peptides in association with major histocompatibility complex (MHC)-encoded molecules. Peptides from the extracellular fluid can be displayed in association with class I and class II MHC molecules. Here we report that mature Kb class I MHC molecules bind peptides upon dissociation and reassociation of their light chain. Intact Kb heterodimers, unlike class II MHC molecules, are relatively unreceptive to binding peptides. This property may maintain segregation of class I and class II MHC-restricted peptides and has implications for the use of peptides as vaccines.

Bibliography

Rock, K. L., Rothstein, L. E., Gamble, S. R., & Benacerraf, B. (1990). Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides. Proceedings of the National Academy of Sciences, 87(19), 7517â7521.

Authors 4

K L Rock (first)
L E Rothstein (additional)
S R Gamble (additional)
B Benacerraf (additional)

References 0 Referenced 57

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:27 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:24 p.m.)
Indexed	1 week, 6 days ago (Aug. 24, 2025, 7:05 p.m.)
Issued	34 years, 11 months ago (Oct. 1, 1990)
Published	34 years, 11 months ago (Oct. 1, 1990)
Published Online	34 years, 11 months ago (Oct. 1, 1990)
Published Print	34 years, 11 months ago (Oct. 1, 1990)

Funders 0

None

BibTeX

@article{Rock_1990, title={Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.}, volume={87}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.87.19.7517}, DOI={10.1073/pnas.87.19.7517}, number={19}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Rock, K L and Rothstein, L E and Gamble, S R and Benacerraf, B}, year={1990}, month=oct, pages={7517–7521} }

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