DOI: 10.1073/pnas.87.10.3723. Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.

Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.

10.1073/pnas.87.10.3723

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The expression of the protooncogenes ETS1 and ETS2 has been studied in purified human T cells activated either by cross-linking of the T-cell receptor-CD3 complex on their cell surface or by direct stimulation with phorbol esters and ionomycin. Our results show that resting T cells express high levels of ETS1 mRNA and protein, while expression of ETS2 is undetectable. Upon T-cell activation, ETS2 mRNA and proteins are induced, while ETS1 gene expression decreases to very low levels. Late after stimulation, ETS1 mRNA is reinduced and maintained at a high level, while ETS2 gene expression decreases to undetectable levels. Therefore, it appears that in human T cells, ETS2 gene products are associated with cellular activation and proliferation, while ETS1 gene products are preferentially expressed in a quiescent state.

Bibliography

Bhat, N. K., Thompson, C. B., Lindsten, T., June, C. H., Fujiwara, S., Koizumi, S., Fisher, R. J., & Papas, T. S. (1990). Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1. Proceedings of the National Academy of Sciences, 87(10), 3723â3727.

Authors 8

N K Bhat (first)
C B Thompson (additional)
T Lindsten (additional)
C H June (additional)
S Fujiwara (additional)
S Koizumi (additional)
R J Fisher (additional)
T S Papas (additional)

References 0 Referenced 104

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:19 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:49 p.m.)
Indexed	1 month, 3 weeks ago (July 11, 2025, 6:27 a.m.)
Issued	35 years, 4 months ago (May 1, 1990)
Published	35 years, 4 months ago (May 1, 1990)
Published Online	35 years, 4 months ago (May 1, 1990)
Published Print	35 years, 4 months ago (May 1, 1990)

Funders 0

None

BibTeX

@article{Bhat_1990, title={Reciprocal expression of human ETS1 and ETS2 genes during T-cell activation: regulatory role for the protooncogene ETS1.}, volume={87}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.87.10.3723}, DOI={10.1073/pnas.87.10.3723}, number={10}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Bhat, N K and Thompson, C B and Lindsten, T and June, C H and Fujiwara, S and Koizumi, S and Fisher, R J and Papas, T S}, year={1990}, month=may, pages={3723–3727} }

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