DOI: 10.1073/pnas.86.24.9798. Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

10.1073/pnas.86.24.9798

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The posttranscriptional regulator (rex) of human T-cell leukemia virus type I is known to be located predominantly in the cell nucleolus and to induce the accumulation of gag and env viral mRNAs. The N-terminal 19 amino acids of rex-encoded protein (Rex) has been shown to be sufficient to direct hybrid proteins to the cell nucleolus. We have studied the function of the nucleolar targeting signal (NOS) of rex by using full-length proviral DNA and mutant rex expression plasmids. Partial deletions of the NOS sequence abolished the accumulation of unspliced cytoplasmic mRNA, although the gene products of rex mutants were found in the nucleoplasm. These results indicate that NOS sequence, or nucleolar localization of Rex, is essential for Rex function.

Bibliography

Nosaka, T., Siomi, H., Adachi, Y., Ishibashi, M., Kubota, S., Maki, M., & Hatanaka, M. (1989). Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA. Proceedings of the National Academy of Sciences, 86(24), 9798â9802.

Authors 7

T Nosaka (first)
H Siomi (additional)
Y Adachi (additional)
M Ishibashi (additional)
S Kubota (additional)
M Maki (additional)
M Hatanaka (additional)

References 0 Referenced 73

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:10 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:58 p.m.)
Indexed	1 year, 1 month ago (July 29, 2024, 8:04 p.m.)
Issued	35 years, 9 months ago (Dec. 1, 1989)
Published	35 years, 9 months ago (Dec. 1, 1989)
Published Online	35 years, 9 months ago (Dec. 1, 1989)
Published Print	35 years, 9 months ago (Dec. 1, 1989)

Funders 0

None

BibTeX

@article{Nosaka_1989, title={Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.}, volume={86}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.86.24.9798}, DOI={10.1073/pnas.86.24.9798}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Nosaka, T and Siomi, H and Adachi, Y and Ishibashi, M and Kubota, S and Maki, M and Hatanaka, M}, year={1989}, month=dec, pages={9798–9802} }

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