DOI: 10.1073/pnas.86.16.6338. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

10.1073/pnas.86.16.6338

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In this study, we use antisera to synthetic beta-amyloid protein precursor (beta APP) peptides to identify, in human brain and cerebrospinal fluid (CSF), soluble approximately 125- and approximately 105-kDa derivatives of the beta APP that lack the carboxyl terminus of the full-length, membrane-associated forms. We show that the soluble approximately 125-kDa beta APP derivative contains the Kunitz protease inhibitor domain, whereas the approximately 105-kDa form does not, and we confirm that these two proteins are soluble beta APP derivatives by purifying each from human CSF and directly sequencing its amino terminus.

Bibliography

Palmert, M. R., Podlisny, M. B., Witker, D. S., Oltersdorf, T., Younkin, L. H., Selkoe, D. J., & Younkin, S. G. (1989). The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proceedings of the National Academy of Sciences, 86(16), 6338â6342.

Authors 7

M R Palmert (first)
M B Podlisny (additional)
D S Witker (additional)
T Oltersdorf (additional)
L H Younkin (additional)
D J Selkoe (additional)
S G Younkin (additional)

References 0 Referenced 157

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 7:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:47 p.m.)
Indexed	4 months, 3 weeks ago (April 5, 2025, 12:50 a.m.)
Issued	36 years ago (Aug. 1, 1989)
Published	36 years ago (Aug. 1, 1989)
Published Online	36 years ago (Aug. 1, 1989)
Published Print	36 years ago (Aug. 1, 1989)

Funders 0

None

BibTeX

@article{Palmert_1989, title={The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.}, volume={86}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.86.16.6338}, DOI={10.1073/pnas.86.16.6338}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Palmert, M R and Podlisny, M B and Witker, D S and Oltersdorf, T and Younkin, L H and Selkoe, D J and Younkin, S G}, year={1989}, month=aug, pages={6338–6342} }

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