DOI: 10.1073/pnas.86.16.6255. A family of cyclin homologs that control the G1 phase in yeast.

A family of cyclin homologs that control the G1 phase in yeast.

10.1073/pnas.86.16.6255

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.

Bibliography

Hadwiger, J. A., Wittenberg, C., Richardson, H. E., de Barros Lopes, M., & Reed, S. I. (1989). A family of cyclin homologs that control the G1 phase in yeast. Proceedings of the National Academy of Sciences, 86(16), 6255â6259.

Authors 5

J A Hadwiger (first)
C Wittenberg (additional)
H E Richardson (additional)
M de Barros Lopes (additional)
S I Reed (additional)

References 0 Referenced 249

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 7:01 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:47 p.m.)
Indexed	3 weeks, 4 days ago (Aug. 7, 2025, 4:30 p.m.)
Issued	36 years, 1 month ago (Aug. 1, 1989)
Published	36 years, 1 month ago (Aug. 1, 1989)
Published Online	36 years, 1 month ago (Aug. 1, 1989)
Published Print	36 years, 1 month ago (Aug. 1, 1989)

Funders 0

None

BibTeX

@article{Hadwiger_1989, title={A family of cyclin homologs that control the G1 phase in yeast.}, volume={86}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.86.16.6255}, DOI={10.1073/pnas.86.16.6255}, number={16}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hadwiger, J A and Wittenberg, C and Richardson, H E and de Barros Lopes, M and Reed, S I}, year={1989}, month=aug, pages={6255–6259} }

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