DOI: 10.1073/pnas.86.14.5459. Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.

Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.

10.1073/pnas.86.14.5459

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Antennapedia-class vertebrate homeobox genes have been classified with regard to their chromosomal locations and nucleotide sequence similarities within the 183-base-pair homeobox domain. The results of these comparisons support the view that in mammals and most likely the vertebrates, four clusters of homeobox genes exist that were created by duplications of an entire primordial gene cluster. We present evidence that this primordial cluster arose by local gene duplications of homeoboxes that were present before the divergence of arthropods and chordates. Sequence analyses indicate that the expansion of the primordial gene cluster complex was accompanied by diversification, whereas conservation predominated after the duplications of entire homeobox gene clusters.

Bibliography

Kappen, C., Schughart, K., & Ruddle, F. H. (1989). Two steps in the evolution of Antennapedia-class vertebrate homeobox genes. Proceedings of the National Academy of Sciences, 86(14), 5459â5463.

Authors 3

C Kappen (first)
K Schughart (additional)
F H Ruddle (additional)

References 0 Referenced 138

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:59 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:45 p.m.)
Indexed	1 month, 2 weeks ago (July 7, 2025, 8:26 a.m.)
Issued	36 years, 1 month ago (July 1, 1989)
Published	36 years, 1 month ago (July 1, 1989)
Published Online	36 years, 1 month ago (July 1, 1989)
Published Print	36 years, 1 month ago (July 1, 1989)

Funders 0

None

BibTeX

@article{Kappen_1989, title={Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.}, volume={86}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.86.14.5459}, DOI={10.1073/pnas.86.14.5459}, number={14}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kappen, C and Schughart, K and Ruddle, F H}, year={1989}, month=jul, pages={5459–5463} }

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