DOI: 10.1073/pnas.86.12.4634. Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.

Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.

10.1073/pnas.86.12.4634

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Recently, hematopoietic stem cells were purified to homogeneity from mouse bone marrow. The protein structure of Sca-1, the cell surface antigen used in the isolation of hematopoietic stem cells, is described here. It is shown that the Sca-1 antigen is a member of the Ly-6 antigen family. The anti-Sca-1 antibody was used in immunohistochemistry experiments to define the structures in several tissues that had previously been shown to contain Ly-6 antigens. In thymus, spleen, and kidney, specific staining of parenchymal cells can be demonstrated, whereas only vasculature reacts with anti-Sca-1 in brain, heart, and liver and possibly in lung.

Bibliography

van de Rijn, M., Heimfeld, S., Spangrude, G. J., & Weissman, I. L. (1989). Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proceedings of the National Academy of Sciences, 86(12), 4634â4638.

Authors 4

M van de Rijn (first)
S Heimfeld (additional)
G J Spangrude (additional)
I L Weissman (additional)

References 0 Referenced 187

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:56 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:01 p.m.)
Indexed	4 weeks, 1 day ago (July 26, 2025, 4:47 a.m.)
Issued	36 years, 2 months ago (June 1, 1989)
Published	36 years, 2 months ago (June 1, 1989)
Published Online	36 years, 2 months ago (June 1, 1989)
Published Print	36 years, 2 months ago (June 1, 1989)

Funders 0

None

BibTeX

@article{van_de_Rijn_1989, title={Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family.}, volume={86}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.86.12.4634}, DOI={10.1073/pnas.86.12.4634}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={van de Rijn, M and Heimfeld, S and Spangrude, G J and Weissman, I L}, year={1989}, month=jun, pages={4634–4638} }

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