DOI: 10.1073/pnas.86.12.4554. Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

10.1073/pnas.86.12.4554

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The transforming growth factor beta (TGF-beta)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-beta superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.

Bibliography

Lyons, K., Graycar, J. L., Lee, A., Hashmi, S., Lindquist, P. B., Chen, E. Y., Hogan, B. L., & Derynck, R. (1989). Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily. Proceedings of the National Academy of Sciences, 86(12), 4554â4558.

Authors 8

K Lyons (first)
J L Graycar (additional)
A Lee (additional)
S Hashmi (additional)
P B Lindquist (additional)
E Y Chen (additional)
B L Hogan (additional)
R Derynck (additional)

References 0 Referenced 115

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:56 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 1:01 p.m.)
Indexed	2 months, 1 week ago (June 25, 2025, 10:47 p.m.)
Issued	36 years, 3 months ago (June 1, 1989)
Published	36 years, 3 months ago (June 1, 1989)
Published Online	36 years, 3 months ago (June 1, 1989)
Published Print	36 years, 3 months ago (June 1, 1989)

Funders 0

None

BibTeX

@article{Lyons_1989, title={Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.}, volume={86}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.86.12.4554}, DOI={10.1073/pnas.86.12.4554}, number={12}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Lyons, K and Graycar, J L and Lee, A and Hashmi, S and Lindquist, P B and Chen, E Y and Hogan, B L and Derynck, R}, year={1989}, month=jun, pages={4554–4558} }

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