DOI: 10.1073/pnas.85.8.2805. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis.

Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis.

10.1073/pnas.85.8.2805

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Native low density lipoprotein (LDL) does not affect monocyte/macrophage motility. On the other hand, oxidatively modified LDL inhibits the motility of resident peritoneal macrophages yet acts as a chemotactic factor for circulating human monocytes. We now show that lysophosphatidylcholine (lyso-PtdCho), which is generated by a phospholipase A2 activity during LDL oxidation, is a potent chemotactic factor for monocytes. It is not chemotactic for neutrophils or for resident macrophages. Platelet-activating factor, after treatment with phospholipase A2, becomes chemotactic for monocytes, whereas the intact factor is not. Synthetic 1-palmitoyl-lyso-PtdCho showed chemotactic activity comparable to that of the lyso-PtdCho fraction derived from oxidized LDL. The results suggest that lyso-PtdCho in oxidized LDL may favor recruitment of monocytes into the arterial wall during the early stages of atherogenesis. Generation of lyso-PtdCho, either from LDL itself or from membrane phospholipids of damaged cells, could play a more general role in inflammatory processes throughout the body.

Bibliography

Quinn, M. T., Parthasarathy, S., & Steinberg, D. (1988). Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. Proceedings of the National Academy of Sciences, 85(8), 2805â2809.

Authors 3

M T Quinn (first)
S Parthasarathy (additional)
D Steinberg (additional)

References 0 Referenced 480

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:53 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:46 p.m.)
Indexed	5 days, 2 hours ago (Aug. 27, 2025, 11:47 a.m.)
Issued	37 years, 5 months ago (April 1, 1988)
Published	37 years, 5 months ago (April 1, 1988)
Published Online	37 years, 5 months ago (April 1, 1988)
Published Print	37 years, 5 months ago (April 1, 1988)

Funders 0

None

BibTeX

@article{Quinn_1988, title={Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.8.2805}, DOI={10.1073/pnas.85.8.2805}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Quinn, M T and Parthasarathy, S and Steinberg, D}, year={1988}, month=apr, pages={2805–2809} }

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