DOI: 10.1073/pnas.85.8.2733. rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.

10.1073/pnas.85.8.2733

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The Rpt-1 (for regulatory protein, T-lymphocyte, 1) gene, selectively expressed by resting but not by activated CD4+ inducer T cells, encodes an intracellular protein (rpt-1, Mr 41,000) that down-regulates gene expression directed by the promoter region of the gene encoding interleukin 2 receptor alpha chain and by the long terminal repeat of human immunodeficiency virus type 1. The data reported here suggest that rpt-1 levels may be inversely correlated with activation of CD4+ T cells and human immunodeficiency virus replication leading to clinical symptoms of the acquired immunodeficiency syndrome.

Authors 10

R Patarca (first)
G J Freeman (additional)
J Schwartz (additional)
R P Singh (additional)
Q T Kong (additional)
E Murphy (additional)
Y Anderson (additional)
F Y Sheng (additional)
P Singh (additional)
K A Johnson (additional)

References 0 Referenced 89

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:53 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:47 p.m.)
Indexed	1 year, 5 months ago (March 4, 2024, 10:23 a.m.)
Issued	37 years, 4 months ago (April 1, 1988)
Published	37 years, 4 months ago (April 1, 1988)
Published Online	37 years, 4 months ago (April 1, 1988)
Published Print	37 years, 4 months ago (April 1, 1988)

Funders 0

None

BibTeX

@article{Patarca_1988, title={rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.8.2733}, DOI={10.1073/pnas.85.8.2733}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Patarca, R and Freeman, G J and Schwartz, J and Singh, R P and Kong, Q T and Murphy, E and Anderson, Y and Sheng, F Y and Singh, P and Johnson, K A}, year={1988}, month=apr, pages={2733–2737} }

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