DOI: 10.1073/pnas.85.8.2638. Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene.

Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene.

10.1073/pnas.85.8.2638

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Induction of differentiation of the human monoblastic cell line U-937 in vitro by several physiologic and nonphysiologic inducers is accompanied by a rapid decrease in expression of MYC, the endogenous human myc protooncogene. To investigate whether this reduction is a prerequisite for terminal differentiation, we introduced a constitutively expressed v-myc gene into U-937 cells. The results show that constitutive expression of an avian v-myc oncogene does not interfere with phorbol 12-myristate 13-acetate-induced differentiation of U-937 cells early after stimulation. However, after 24 hr the differentiation process is reversed, as judged by a full recovery of the proliferative capacity and reexpression of the immature phenotype, within the next 2-4 days. We conclude that the terminal stage of macrophage differentiation is inhibited in U-937 cells constitutively expressing a v-myc oncogene.

Bibliography

Larsson, L. G., Ivhed, I., Gidlund, M., Pettersson, U., VennstrÃ¶m, B., & Nilsson, K. (1988). Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene. Proceedings of the National Academy of Sciences, 85(8), 2638â2642.

Authors 6

L G Larsson (first)
I Ivhed (additional)
M Gidlund (additional)
U Pettersson (additional)
B Vennström (additional)
K Nilsson (additional)

References 0 Referenced 61

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:53 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:47 p.m.)
Indexed	1 year, 7 months ago (Jan. 12, 2024, 11:01 p.m.)
Issued	37 years, 4 months ago (April 1, 1988)
Published	37 years, 4 months ago (April 1, 1988)
Published Online	37 years, 4 months ago (April 1, 1988)
Published Print	37 years, 4 months ago (April 1, 1988)

Funders 0

None

BibTeX

@article{Larsson_1988, title={Phorbol ester-induced terminal differentiation is inhibited in human U-937 monoblastic cells expressing a v-myc oncogene.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.8.2638}, DOI={10.1073/pnas.85.8.2638}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Larsson, L G and Ivhed, I and Gidlund, M and Pettersson, U and Vennström, B and Nilsson, K}, year={1988}, month=apr, pages={2638–2642} }

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