DOI: 10.1073/pnas.85.7.2215. Localization of the human JUN protooncogene to chromosome region 1p31-32.

Localization of the human JUN protooncogene to chromosome region 1p31-32.

10.1073/pnas.85.7.2215

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The oncogene jun is the putative transforming gene of avian sarcoma virus 17; jun appears to be derived from a gene of the chicken genome and has homologues in several other vertebrate species. Recent genetic and immunological data indicate that jun codes for a protein that is closely related and probably identical to the transcription factor AP-1. We have isolated a genomic DNA clone encompassing the human cellular counterpart of the gene, JUN, and used this DNA to determine the chromosomal location of the gene. A panel of DNA preparations derived from rodent-human somatic cell hybrids with defined chromosome complements was first screened with the JUN probe. This Southern blot analysis indicated that JUN is situated on the short arm of chromosome 1. In situ hybridization then assigned JUN to chromosome region 1p31-32, a chromosomal region involved in both translocations and deletions of chromosomes seen in human malignancies.

Bibliography

Haluska, F. G., Huebner, K., Isobe, M., Nishimura, T., Croce, C. M., & Vogt, P. K. (1988). Localization of the human JUN protooncogene to chromosome region 1p31-32. Proceedings of the National Academy of Sciences, 85(7), 2215â2218.

Authors 6

F G Haluska (first)
K Huebner (additional)
M Isobe (additional)
T Nishimura (additional)
C M Croce (additional)
P K Vogt (additional)

References 0 Referenced 38

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:51 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:38 p.m.)
Indexed	4 months, 3 weeks ago (April 8, 2025, 10:18 p.m.)
Issued	37 years, 4 months ago (April 1, 1988)
Published	37 years, 4 months ago (April 1, 1988)
Published Online	37 years, 4 months ago (April 1, 1988)
Published Print	37 years, 4 months ago (April 1, 1988)

Funders 0

None

BibTeX

@article{Haluska_1988, title={Localization of the human JUN protooncogene to chromosome region 1p31-32.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.7.2215}, DOI={10.1073/pnas.85.7.2215}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Haluska, F G and Huebner, K and Isobe, M and Nishimura, T and Croce, C M and Vogt, P K}, year={1988}, month=apr, pages={2215–2218} }

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