DOI: 10.1073/pnas.85.19.7322. Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.

10.1073/pnas.85.19.7322

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The expression of HLA class II genes is regulated by a series of cis-acting elements and trans-acting factors. Several cis-acting elements have been identified and have been termed the Z box, X box, Y box, octamer, and "TATA" box. The Y box contains an inverted CCAAT box. By probing a phage lambda gt11 library with double-stranded oligonucleotides, we have directly isolated a cDNA encoding a Y box-binding protein designated YB-1. YB-1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a Mr of 35,414, contains 18% basic residues, and contains putative nuclear localization signals. An inverse correlation of YB-1 and HLA-DR beta chain mRNA levels suggests that YB-1 is a negative regulatory factor.

Bibliography

Didier, D. K., Schiffenbauer, J., Woulfe, S. L., Zacheis, M., & Schwartz, B. D. (1988). Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box. Proceedings of the National Academy of Sciences, 85(19), 7322â7326.

Authors 5

D K Didier (first)
J Schiffenbauer (additional)
S L Woulfe (additional)
M Zacheis (additional)
B D Schwartz (additional)

References 0 Referenced 293

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:43 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:49 p.m.)
Indexed	1 month, 3 weeks ago (July 1, 2025, 9:07 a.m.)
Issued	36 years, 10 months ago (Oct. 1, 1988)
Published	36 years, 10 months ago (Oct. 1, 1988)
Published Online	36 years, 10 months ago (Oct. 1, 1988)
Published Print	36 years, 10 months ago (Oct. 1, 1988)

Funders 0

None

BibTeX

@article{Didier_1988, title={Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.19.7322}, DOI={10.1073/pnas.85.19.7322}, number={19}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Didier, D K and Schiffenbauer, J and Woulfe, S L and Zacheis, M and Schwartz, B D}, year={1988}, month=oct, pages={7322–7326} }

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