DOI: 10.1073/pnas.85.18.6622. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

10.1073/pnas.85.18.6622

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A highly conserved repetitive DNA sequence, (TTAGGG)n, has been isolated from a human recombinant repetitive DNA library. Quantitative hybridization to chromosomes sorted by flow cytometry indicates that comparable amounts of this sequence are present on each human chromosome. Both fluorescent in situ hybridization and BAL-31 nuclease digestion experiments reveal major clusters of this sequence at the telomeres of all human chromosomes. The evolutionary conservation of this DNA sequence, its terminal chromosomal location in a variety of higher eukaryotes (regardless of chromosome number or chromosome length), and its similarity to functional telomeres isolated from lower eukaryotes suggest that this sequence is a functional human telomere.

Bibliography

Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988). A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proceedings of the National Academy of Sciences, 85(18), 6622â6626.

Authors 9

R K Moyzis (first)
J M Buckingham (additional)
L S Cram (additional)
M Dani (additional)
L L Deaven (additional)
M D Jones (additional)
J Meyne (additional)
R L Ratliff (additional)
J R Wu (additional)

References 0 Referenced 1,673

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:41 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:43 p.m.)
Indexed	35 minutes ago (Aug. 27, 2025, 7:57 a.m.)
Issued	36 years, 11 months ago (Sept. 1, 1988)
Published	36 years, 11 months ago (Sept. 1, 1988)
Published Online	36 years, 11 months ago (Sept. 1, 1988)
Published Print	36 years, 11 months ago (Sept. 1, 1988)

Funders 0

None

BibTeX

@article{Moyzis_1988, title={A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.18.6622}, DOI={10.1073/pnas.85.18.6622}, number={18}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Moyzis, R K and Buckingham, J M and Cram, L S and Dani, M and Deaven, L L and Jones, M D and Meyne, J and Ratliff, R L and Wu, J R}, year={1988}, month=sep, pages={6622–6626} }

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