DOI: 10.1073/pnas.85.15.5507. Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

10.1073/pnas.85.15.5507

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Twenty different target sites within human immunodeficiency virus (HIV) RNA were selected for studies of inhibition of HIV replication by antisense oligonucleotides. Target sites were selected based on their potential capacity to block recognition functions during viral replication. Antisense oligomers complementary to sites within or near the sequence repeated at the ends of retrovirus RNA (R region) and to certain splice sites were most effective. The effect of antisense oligomer length on inhibiting virus replication was also investigated, and preliminary toxicity studies in mice show that these compounds are toxic only at high levels. The results indicate potential usefulness for these oligomers in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex either alone or in combination with other drugs.

Bibliography

Goodchild, J., Agrawal, S., Civeira, M. P., Sarin, P. S., Sun, D., & Zamecnik, P. C. (1988). Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides. Proceedings of the National Academy of Sciences, 85(15), 5507â5511.

Authors 6

J Goodchild (first)
S Agrawal (additional)
M P Civeira (additional)
P S Sarin (additional)
D Sun (additional)
P C Zamecnik (additional)

References 0 Referenced 149

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:40 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:41 p.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:07 a.m.)
Issued	37 years, 1 month ago (Aug. 1, 1988)
Published	37 years, 1 month ago (Aug. 1, 1988)
Published Online	37 years, 1 month ago (Aug. 1, 1988)
Published Print	37 years, 1 month ago (Aug. 1, 1988)

Funders 0

None

BibTeX

@article{Goodchild_1988, title={Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.}, volume={85}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.85.15.5507}, DOI={10.1073/pnas.85.15.5507}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Goodchild, J and Agrawal, S and Civeira, M P and Sarin, P S and Sun, D and Zamecnik, P C}, year={1988}, month=aug, pages={5507–5511} }

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