DOI: 10.1073/pnas.84.7.1940. A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein.

A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein.

10.1073/pnas.84.7.1940

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Human peripheral blood leukocytes can stimulate G1(G0)-arrested mouse skin keratinocytes to enter the cell cycle again and synthesize DNA at the maximum rate 15-20 hr later. This growth-promoting activity is released by the monocyte fraction and is shown to have characteristics that have been reported for interleukin 1 (IL-1). Pure IL-1 is active in stimulating keratinocyte cultures as was shown with recombinant human IL-1. An IL-1-like protein released by monocytes-macrophages could explain the hyperproliferative epidermis found in certain types of inflammatory skin diseases.

Bibliography

Ristow, H. J. (1987). A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein. Proceedings of the National Academy of Sciences, 84(7), 1940â1944.

Authors 1

H J Ristow (first)

References 0 Referenced 90

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:32 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:54 p.m.)
Indexed	1 year, 8 months ago (Dec. 26, 2023, 5:27 p.m.)
Issued	38 years, 4 months ago (April 1, 1987)
Published	38 years, 4 months ago (April 1, 1987)
Published Online	38 years, 4 months ago (April 1, 1987)
Published Print	38 years, 4 months ago (April 1, 1987)

Funders 0

None

BibTeX

@article{Ristow_1987, title={A major factor contributing to epidermal proliferation in inflammatory skin diseases appears to be interleukin 1 or a related protein.}, volume={84}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.84.7.1940}, DOI={10.1073/pnas.84.7.1940}, number={7}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Ristow, H J}, year={1987}, month=apr, pages={1940–1944} }

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