DOI: 10.1073/pnas.84.24.9270. Expression and rearrangement of the ROS1 gene in human glioblastoma cells.

Expression and rearrangement of the ROS1 gene in human glioblastoma cells.

10.1073/pnas.84.24.9270

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The human ROS1 gene, which possibly encodes a growth factor receptor, was found to be expressed in human tumor cell lines. In a survey of 45 different human cell lines, we found ROS1 to be expressed in glioblastoma-derived cell lines at high levels and not to be expressed at all, or expressed at very low levels, in the remaining cell lines. The ROS1 gene was present in normal copy numbers in all cell lines that expressed the gene. However, in one particular glioblastoma line, we detected a potentially activating mutation at the ROS1 locus.

Bibliography

Birchmeier, C., Sharma, S., & Wigler, M. (1987). Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proceedings of the National Academy of Sciences, 84(24), 9270â9274.

Authors 3

C Birchmeier (first)
S Sharma (additional)
M Wigler (additional)

References 0 Referenced 175

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:30 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:23 p.m.)
Indexed	1 month ago (July 26, 2025, 5:21 a.m.)
Issued	37 years, 8 months ago (Dec. 1, 1987)
Published	37 years, 8 months ago (Dec. 1, 1987)
Published Online	37 years, 8 months ago (Dec. 1, 1987)
Published Print	37 years, 8 months ago (Dec. 1, 1987)

Funders 0

None

BibTeX

@article{Birchmeier_1987, title={Expression and rearrangement of the ROS1 gene in human glioblastoma cells.}, volume={84}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.84.24.9270}, DOI={10.1073/pnas.84.24.9270}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Birchmeier, C and Sharma, S and Wigler, M}, year={1987}, month=dec, pages={9270–9274} }

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