DOI: 10.1073/pnas.84.20.7061. Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

10.1073/pnas.84.20.7061

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In herpes simplex virus 1-infected cells, the transcription of alpha genes, the first set of genes to be expressed, is induced by a virion component, the alpha-trans-induction factor, and requires a cis site. Homologs of the cis site are present in the promoter-regulatory domains of all alpha genes and bind two cellular proteins designated as alpha H1 and alpha H2-alpha H3. We report that alpha-trans-induction factor, synthesized in vitro or present in nuclear extracts of infected cells, forms complexes with viral DNA fragments containing its cis-acting site only in the presence of cellular proteins and only under conditions that also enable the binding of the alpha H1 protein to the DNA. The induction of alpha genes by alpha-trans-induction factor appears, therefore, to be mediated by the interaction of the viral protein with cellular proteins at its cis-acting site.

Bibliography

McKnight, J. L., Kristie, T. M., & Roizman, B. (1987). Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins. Proceedings of the National Academy of Sciences, 84(20), 7061â7065.

Authors 3

J L McKnight (first)
T M Kristie (additional)
B Roizman (additional)

References 0 Referenced 153

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:26 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:36 p.m.)
Indexed	4 months, 2 weeks ago (April 11, 2025, 6:27 a.m.)
Issued	37 years, 10 months ago (Oct. 1, 1987)
Published	37 years, 10 months ago (Oct. 1, 1987)
Published Online	37 years, 10 months ago (Oct. 1, 1987)
Published Print	37 years, 10 months ago (Oct. 1, 1987)

Funders 0

None

BibTeX

@article{McKnight_1987, title={Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.}, volume={84}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.84.20.7061}, DOI={10.1073/pnas.84.20.7061}, number={20}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={McKnight, J L and Kristie, T M and Roizman, B}, year={1987}, month=oct, pages={7061–7065} }

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