DOI: 10.1073/pnas.83.9.3032. Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels.

Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels.

10.1073/pnas.83.9.3032

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We have used a three-dimensional diffusion model of calcium entering the presynaptic nerve terminal through discrete channels to simulate experiments relating transmitter release to presynaptic calcium current. The relationship will be less than linear, or will curve downward, if calcium channels are well separated. It will resemble a power-law function with exponent less than the cooperativity of calcium action if channels are clustered closer together. Large presynaptic depolarizations elicit more release than small depolarizations admitting the same calcium influx. This occurs because large pulses open more channels near each other, with the result that the calcium concentration near release sites is greater, due to overlap of calcium diffusing from adjacent channels.

Bibliography

Zucker, R. S., & Fogelson, A. L. (1986). Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels. Proceedings of the National Academy of Sciences, 83(9), 3032â3036.

Authors 2

R S Zucker (first)
A L Fogelson (additional)

References 0 Referenced 120

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:48 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:26 p.m.)
Indexed	1 month, 3 weeks ago (July 7, 2025, 2:28 a.m.)
Issued	39 years, 3 months ago (May 1, 1986)
Published	39 years, 3 months ago (May 1, 1986)
Published Online	39 years, 3 months ago (May 1, 1986)
Published Print	39 years, 3 months ago (May 1, 1986)

Funders 0

None

BibTeX

@article{Zucker_1986, title={Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels.}, volume={83}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.83.9.3032}, DOI={10.1073/pnas.83.9.3032}, number={9}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Zucker, R S and Fogelson, A L}, year={1986}, month=may, pages={3032–3036} }

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