DOI: 10.1073/pnas.83.6.1608. On the specificity of DNA-protein interactions.

On the specificity of DNA-protein interactions.

10.1073/pnas.83.6.1608

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In this paper we summarize the various factors that must be considered in establishing the operational specificity of the binding of a protein regulator of gene expression to a DNA target site. We consider informational (combinatorial) aspects of binding-site specification, actual recognition mechanisms, and the thermodynamics of target-site selection against a background of competing pseudospecific and non-(sequence)-specific DNA binding sites. The results provide insight into the design, specification, and possibly the evolution of regulatory proteins and their chromosomal binding targets, as well as into practical aspects of the design of regulatory-protein isolation schemes and physicochemical regulatory considerations in vivo.

Bibliography

von Hippel, P. H., & Berg, O. G. (1986). On the specificity of DNA-protein interactions. Proceedings of the National Academy of Sciences, 83(6), 1608â1612.

Authors 2

P H von Hippel (first)
O G Berg (additional)

References 0 Referenced 242

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:15 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:34 p.m.)
Indexed	3 weeks, 5 days ago (Aug. 6, 2025, 9:31 a.m.)
Issued	39 years, 6 months ago (March 1, 1986)
Published	39 years, 6 months ago (March 1, 1986)
Published Online	39 years, 6 months ago (March 1, 1986)
Published Print	39 years, 6 months ago (March 1, 1986)

Funders 0

None

BibTeX

@article{von_Hippel_1986, title={On the specificity of DNA-protein interactions.}, volume={83}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.83.6.1608}, DOI={10.1073/pnas.83.6.1608}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={von Hippel, P H and Berg, O G}, year={1986}, month=mar, pages={1608–1612} }

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