DOI: 10.1073/pnas.83.2.470. Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.

Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.

10.1073/pnas.83.2.470

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Amplified cellular genes are frequently manifested in one of two cytologically recognizable forms, double minutes or homogeneously staining regions. Additionally, evidence is accumulating that aberrant expression of cellular genes (including oncogenes) may be mediated by gene amplification. We now describe the amplification and expression of the cellular oncogene c-myc in double-minute-containing cells from a patient with glioblastoma multiforme, and we have shown that the amplification is associated with rearrangement of the c-myc gene. This finding further supports the common association of the myc gene family in neurogenic tumors and provides evidence of myc gene amplification in human brain cancer.

Bibliography

Trent, J., Meltzer, P., Rosenblum, M., Harsh, G., Kinzler, K., Mashal, R., Feinberg, A., & Vogelstein, B. (1986). Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proceedings of the National Academy of Sciences, 83(2), 470â473.

Authors 8

J Trent (first)
P Meltzer (additional)
M Rosenblum (additional)
G Harsh (additional)
K Kinzler (additional)
R Mashal (additional)
A Feinberg (additional)
B Vogelstein (additional)

References 0 Referenced 114

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:07 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:34 p.m.)
Indexed	1 day, 5 hours ago (Aug. 31, 2025, 6:11 a.m.)
Issued	39 years, 8 months ago (Jan. 1, 1986)
Published	39 years, 8 months ago (Jan. 1, 1986)
Published Online	39 years, 8 months ago (Jan. 1, 1986)
Published Print	39 years, 8 months ago (Jan. 1, 1986)

Funders 0

None

BibTeX

@article{Trent_1986, title={Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.}, volume={83}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.83.2.470}, DOI={10.1073/pnas.83.2.470}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Trent, J and Meltzer, P and Rosenblum, M and Harsh, G and Kinzler, K and Mashal, R and Feinberg, A and Vogelstein, B}, year={1986}, month=jan, pages={470–473} }

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