DOI: 10.1073/pnas.83.15.5459. yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

10.1073/pnas.83.15.5459

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

An src/yes-related novel gene named syn (SYN in human gene nomenclature) has been identified in the human genome on chromosome 6 and characterized by molecular cloning. Nucleotide sequence analysis of cDNA clones showed that the c-syn gene could encode a protein-tyrosine kinase that is very similar in primary structure to the v-yes and human c-src proteins. A 2.8-kilobase transcript of the c-syn gene, which differs in size from those of the c-yes, c-src, and c-fgr genes, was observed in various cell types. These results show that syn is a new member of the tyrosine kinase oncogene family.

Bibliography

Semba, K., Nishizawa, M., Miyajima, N., Yoshida, M. C., Sukegawa, J., Yamanashi, Y., Sasaki, M., Yamamoto, T., & Toyoshima, K. (1986). yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proceedings of the National Academy of Sciences, 83(15), 5459â5463.

Authors 9

K Semba (first)
M Nishizawa (additional)
N Miyajima (additional)
M C Yoshida (additional)
J Sukegawa (additional)
Y Yamanashi (additional)
M Sasaki (additional)
T Yamamoto (additional)
K Toyoshima (additional)

References 0 Referenced 134

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 6:02 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:18 p.m.)
Indexed	3 weeks, 6 days ago (Aug. 7, 2025, 4:49 p.m.)
Issued	39 years, 1 month ago (Aug. 1, 1986)
Published	39 years, 1 month ago (Aug. 1, 1986)
Published Online	39 years, 1 month ago (Aug. 1, 1986)
Published Print	39 years, 1 month ago (Aug. 1, 1986)

Funders 0

None

BibTeX

@article{Semba_1986, title={yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.}, volume={83}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.83.15.5459}, DOI={10.1073/pnas.83.15.5459}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Semba, K and Nishizawa, M and Miyajima, N and Yoshida, M C and Sukegawa, J and Yamanashi, Y and Sasaki, M and Yamamoto, T and Toyoshima, K}, year={1986}, month=aug, pages={5459–5463} }

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