DOI: 10.1073/pnas.83.14.5326. Hebbian synapses in hippocampus.

10.1073/pnas.83.14.5326

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A combination of current- and voltage-clamp techniques applied to hippocampal brain slices was used to evaluate the role of postsynaptic electrogenesis in the induction of associative synaptic enhancement. In accordance with Hebb's postulate for learning, repetitive postsynaptic spiking enabled enhancement in just those synapses that were eligible to change by virtue of concurrent presynaptic activity. However, the essential postsynaptic electrogenic event that controlled the enhancement was shown to involve biophysical processes that were unknown when Hebb formulated his neurophysiological postulate. The demonstrated spatiotemporal specificity of this pseudo-Hebbian conjunctive mechanism can account qualitatively for the known neurophysiological properties of associative long-term potentiation in these synapses, which in turn can explain the "cooperativity" requirement for long-term potentiation.

Bibliography

Kelso, S. R., Ganong, A. H., & Brown, T. H. (1986). Hebbian synapses in hippocampus. Proceedings of the National Academy of Sciences, 83(14), 5326â5330.

Authors 3

S R Kelso (first)
A H Ganong (additional)
T H Brown (additional)

References 0 Referenced 330

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:02 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:29 p.m.)
Indexed	1 month, 3 weeks ago (June 30, 2025, 9:07 a.m.)
Issued	39 years, 1 month ago (July 1, 1986)
Published	39 years, 1 month ago (July 1, 1986)
Published Online	39 years, 1 month ago (July 1, 1986)
Published Print	39 years, 1 month ago (July 1, 1986)

Funders 0

None

BibTeX

@article{Kelso_1986, title={Hebbian synapses in hippocampus.}, volume={83}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.83.14.5326}, DOI={10.1073/pnas.83.14.5326}, number={14}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Kelso, S R and Ganong, A H and Brown, T H}, year={1986}, month=jul, pages={5326–5330} }

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