DOI: 10.1073/pnas.83.14.5057. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

10.1073/pnas.83.14.5057

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein specifically binds to DNA regions containing a single base-pair mismatch. The protein displayed variable affinity for the limited set of mismatches tested (G-T greater than G-A approximately equal to A-C greater than T-C).

Bibliography

Su, S. S., & Modrich, P. (1986). Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proceedings of the National Academy of Sciences, 83(14), 5057â5061.

Authors 2

S S Su (first)
P Modrich (additional)

References 0 Referenced 257

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 6:02 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:29 p.m.)
Indexed	1 month ago (July 26, 2025, 4:56 a.m.)
Issued	39 years, 1 month ago (July 1, 1986)
Published	39 years, 1 month ago (July 1, 1986)
Published Online	39 years, 1 month ago (July 1, 1986)
Published Print	39 years, 1 month ago (July 1, 1986)

Funders 0

None

BibTeX

@article{Su_1986, title={Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.}, volume={83}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.83.14.5057}, DOI={10.1073/pnas.83.14.5057}, number={14}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Su, S S and Modrich, P}, year={1986}, month=jul, pages={5057–5061} }

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