DOI: 10.1073/pnas.82.6.1697. Structure of proteins with single-site mutations: a minimum perturbation approach.

Structure of proteins with single-site mutations: a minimum perturbation approach.

10.1073/pnas.82.6.1697

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

A large number of mutant proteins with single amino acid substitutions are now being produced. The ability to predict the structural changes expected from such mutations would aid greatly in the efficient utilization of the mutagenic techniques and in the interpretation of the changes in stability and function that result. A minimum perturbation approach is suggested as a first step in such structural predictions and is tested by application to a recently isolated variant of the hemagglutinin glycoprotein. The agreement between the predicted structure and that inferred from the x-ray refinement is encouraging and provides support for the proposed modeling procedure.

Bibliography

Shih, H. H., Brady, J., & Karplus, M. (1985). Structure of proteins with single-site mutations: a minimum perturbation approach. Proceedings of the National Academy of Sciences, 82(6), 1697â1700.

Authors 3

H H Shih (first)
J Brady (additional)
M Karplus (additional)

References 0 Referenced 49

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:45 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:19 p.m.)
Indexed	1 year, 6 months ago (Feb. 10, 2024, 3:03 p.m.)
Issued	40 years, 5 months ago (March 1, 1985)
Published	40 years, 5 months ago (March 1, 1985)
Published Online	40 years, 5 months ago (March 1, 1985)
Published Print	40 years, 5 months ago (March 1, 1985)

Funders 0

None

BibTeX

@article{Shih_1985, title={Structure of proteins with single-site mutations: a minimum perturbation approach.}, volume={82}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.82.6.1697}, DOI={10.1073/pnas.82.6.1697}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Shih, H H and Brady, J and Karplus, M}, year={1985}, month=mar, pages={1697–1700} }

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