DOI: 10.1073/pnas.82.6.1609. Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene.

Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene.

10.1073/pnas.82.6.1609

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We report here the complete nucleotide sequence of a gene encoding the 50-kDa keratin expressed in abundance in human epidermal cells. According to its sequence, this gene has a single transcriptional initiation site and a single polyadenylylation signal. Nuclease S1 mapping of this gene with total human epidermal mRNA confirmed the presence of a single initiation site for the 50-kDa keratin gene. When the regulatory sequences 5' upstream from this gene were examined, three sequences that share significant homology with viral and immunoglobulin enhancer elements were found. In comparison, the sequence of the regulatory region of vimentin, a structurally similar intermediate filament gene, was highly divergent [Quax, W., Egberts, W. V., Hendriks, W., Quax-Jeuken, Y. & Bloemendal, H. (1983) Cell 35, 215-223]. This finding may provide a clue to understanding the molecular mechanisms underlying the widely varying levels of expression of different intermediate filament genes in different tissues.

Bibliography

Marchuk, D., McCrohon, S., & Fuchs, E. (1985). Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proceedings of the National Academy of Sciences, 82(6), 1609â1613.

Authors 3

D Marchuk (first)
S McCrohon (additional)
E Fuchs (additional)

References 0 Referenced 92

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:45 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:20 p.m.)
Indexed	4 months, 3 weeks ago (April 6, 2025, 1:24 p.m.)
Issued	40 years, 5 months ago (March 1, 1985)
Published	40 years, 5 months ago (March 1, 1985)
Published Online	40 years, 5 months ago (March 1, 1985)
Published Print	40 years, 5 months ago (March 1, 1985)

Funders 0

None

BibTeX

@article{Marchuk_1985, title={Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene.}, volume={82}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.82.6.1609}, DOI={10.1073/pnas.82.6.1609}, number={6}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Marchuk, D and McCrohon, S and Fuchs, E}, year={1985}, month=mar, pages={1609–1613} }

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