Crossref journal-article
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences (341)
Abstract

A synthetic peptide (Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr), homologous to the amino terminus of a protein purified from cerebrovascular amyloid (beta protein), induced antibodies in BALB/c mice that were used immunohistochemically to stain not only amyloid-laden cerebral vessels but neuritic plaques as well. These findings suggest that the amyloid in neuritic plaques shares antigenic determinants with beta protein of cerebral vessels. Since the amino acid compositions of plaque amyloid and cerebrovascular amyloid are similar, it is likely that plaque amyloid also consists of beta protein. This possibility suggests a model for the pathogenesis of Alzheimer disease involving beta protein.

Bibliography

Wong, C. W., Quaranta, V., & Glenner, G. G. (1985). Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related. Proceedings of the National Academy of Sciences, 82(24), 8729–8732.

Authors 3
  1. C W Wong (first)
  2. V Quaranta (additional)
  3. G G Glenner (additional)
References 0 Referenced 276

None

Dates
Type When
Created 19 years, 2 months ago (May 31, 2006, 5:50 a.m.)
Deposited 3 years, 4 months ago (April 13, 2022, 12:24 p.m.)
Indexed 18 minutes ago (Aug. 27, 2025, 1:05 a.m.)
Issued 39 years, 8 months ago (Dec. 1, 1985)
Published 39 years, 8 months ago (Dec. 1, 1985)
Published Online 39 years, 8 months ago (Dec. 1, 1985)
Published Print 39 years, 8 months ago (Dec. 1, 1985)
Funders 0

None

@article{Wong_1985, title={Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are antigenically related.}, volume={82}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.82.24.8729}, DOI={10.1073/pnas.82.24.8729}, number={24}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Wong, C W and Quaranta, V and Glenner, G G}, year={1985}, month=dec, pages={8729–8732} }