DOI: 10.1073/pnas.82.22.7666. Variation among human 28S ribosomal RNA genes.

Variation among human 28S ribosomal RNA genes.

10.1073/pnas.82.22.7666

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

We report the complete 5025-base sequence of the human 28S rRNA gene. Variability within the species has been demonstrated by sequencing a variable region from six separately cloned genes. This region is one of three large subunit rRNA regions that show extreme sequence and size variation among species. The interspecies differences suggest species-specific functions for these sections, while the intraspecies heterogeneity indicates differences among ribosomes. Comparison of the human gene with a partial sequence from the chimpanzee 28S gene yields divergence rates for the two species: 0.8% for conserved regions of the gene and 3.7% for a variable region. The rapid divergence rates of variable regions in the ribosomal gene may permit answers to the question of time of separation of closely related species.

Bibliography

Gonzalez, I. L., Gorski, J. L., Campen, T. J., Dorney, D. J., Erickson, J. M., Sylvester, J. E., & Schmickel, R. D. (1985). Variation among human 28S ribosomal RNA genes. Proceedings of the National Academy of Sciences, 82(22), 7666â7670.

Authors 7

I L Gonzalez (first)
J L Gorski (additional)
T J Campen (additional)
D J Dorney (additional)
J M Erickson (additional)
J E Sylvester (additional)
R D Schmickel (additional)

References 0 Referenced 157

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 5:50 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:19 p.m.)
Indexed	1 month, 4 weeks ago (July 2, 2025, 2:46 p.m.)
Issued	39 years, 10 months ago (Nov. 1, 1985)
Published	39 years, 10 months ago (Nov. 1, 1985)
Published Online	39 years, 10 months ago (Nov. 1, 1985)
Published Print	39 years, 10 months ago (Nov. 1, 1985)

Funders 0

None

BibTeX

@article{Gonzalez_1985, title={Variation among human 28S ribosomal RNA genes.}, volume={82}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.82.22.7666}, DOI={10.1073/pnas.82.22.7666}, number={22}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Gonzalez, I L and Gorski, J L and Campen, T J and Dorney, D J and Erickson, J M and Sylvester, J E and Schmickel, R D}, year={1985}, month=nov, pages={7666–7670} }

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