DOI: 10.1073/pnas.82.2.531. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.

Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.

10.1073/pnas.82.2.531

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The functionally defined sets of T lymphocytes--helper T cells, cytotoxic T cells, and suppressor T cells--were examined for the possible involvement of a recently identified T-cell receptor beta gene locus in receptor formation. Since gene rearrangements are required for functional gene expression, cloned T-cell lines from each of the groups were surveyed for the expression of unique gene rearrangements. In addition, cell lines that showed gene rearrangements were further tested for the expression of the mature 1.2- to 1.3-kilobase mRNA transcribed from a productive gene rearrangement. The results of such experiments show that helper and cytotoxic T cells may use a common beta chain of the receptor, whereas suppressor cells do so rarely, if at all.

Bibliography

Hedrick, S. M., Germain, R. N., Bevan, M. J., Dorf, M., Engel, I., Fink, P., Gascoigne, N., Heber-Katz, E., Kapp, J., & Kaufmann, Y. (1985). Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proceedings of the National Academy of Sciences, 82(2), 531â535.

Authors 10

S M Hedrick (first)
R N Germain (additional)
M J Bevan (additional)
M Dorf (additional)
I Engel (additional)
P Fink (additional)
N Gascoigne (additional)
E Heber-Katz (additional)
J Kapp (additional)
Y Kaufmann (additional)

References 0 Referenced 65

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 5:47 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 12:18 p.m.)
Indexed	4 months, 3 weeks ago (April 11, 2025, 7:26 a.m.)
Issued	40 years, 8 months ago (Jan. 1, 1985)
Published	40 years, 8 months ago (Jan. 1, 1985)
Published Online	40 years, 8 months ago (Jan. 1, 1985)
Published Print	40 years, 8 months ago (Jan. 1, 1985)

Funders 0

None

BibTeX

@article{Hedrick_1985, title={Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.}, volume={82}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.82.2.531}, DOI={10.1073/pnas.82.2.531}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Hedrick, S M and Germain, R N and Bevan, M J and Dorf, M and Engel, I and Fink, P and Gascoigne, N and Heber-Katz, E and Kapp, J and Kaufmann, Y}, year={1985}, month=jan, pages={531–535} }

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