DOI: 10.1073/pnas.82.15.4954. A predicted structure of calmodulin suggests an electrostatic basis for its function.

A predicted structure of calmodulin suggests an electrostatic basis for its function.

10.1073/pnas.82.15.4954

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

By using interactive computer graphics, two models for calmodulin have been constructed based on the structures of two functionally and structurally related proteins, intestinal calcium-binding protein and carp parvalbumin. The two models have been compared and contrasted to the parent proteins with respect to proportion of solvent-exposed hydrophobic residues, solvent-accessible surface area, and side-chain packing. Electrostatic potential surfaces generated for the models suggest a probable binding site for basic amphiphilic alpha-helical peptides located between the last E and F helices in the second domain of calmodulin. Both electrostatic and hydrophobic complementarity can contribute to stabilization of a peptide-protein complex in this region.

Bibliography

OâNeil, K. T., & DeGrado, W. F. (1985). A predicted structure of calmodulin suggests an electrostatic basis for its function. Proceedings of the National Academy of Sciences, 82(15), 4954â4958.

Authors 2

K T O'Neil (first)
W F DeGrado (additional)

References 0 Referenced 33

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 5:44 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:49 a.m.)
Indexed	1 year, 10 months ago (Oct. 31, 2023, 4:11 p.m.)
Issued	40 years, 1 month ago (Aug. 1, 1985)
Published	40 years, 1 month ago (Aug. 1, 1985)
Published Online	40 years, 1 month ago (Aug. 1, 1985)
Published Print	40 years, 1 month ago (Aug. 1, 1985)

Funders 0

None

BibTeX

@article{O_Neil_1985, title={A predicted structure of calmodulin suggests an electrostatic basis for its function.}, volume={82}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.82.15.4954}, DOI={10.1073/pnas.82.15.4954}, number={15}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={O’Neil, K T and DeGrado, W F}, year={1985}, month=aug, pages={4954–4958} }

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