DOI: 10.1073/pnas.81.4.1057. 3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.

3' editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.

10.1073/pnas.81.4.1057

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

In vitro-synthesized transcripts of the sea urchin histone H2A gene with 3' extensions are efficiently and rapidly processed to H2A mRNA with faithful 3' ends in Xenopus laevis oocyte nuclei. Processing requires the presence of a histone-specific dyad symmetry element and of H2A-proximal spacer sequences in the precursor RNA. In DNA injection experiments with a processing-deficient H2A mutant, the transcription products appear to terminate heterogeneously in the first 100-200 base pairs of the post-H2A spacer. Processing of synthetic H3 RNA precursors requires the prior injection of a 60-nucleotide RNA from sea urchin embryos that seems to be a component of a small nuclear ribonucleoprotein.

Bibliography

Birchmeier, C., SchÃ¼mperli, D., Sconzo, G., & Birnstiel, M. L. (1984). 3â editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors. Proceedings of the National Academy of Sciences, 81(4), 1057â1061.

Authors 4

C Birchmeier (first)
D Schümperli (additional)
G Sconzo (additional)
M L Birnstiel (additional)

References 0 Referenced 63

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 5:36 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:55 a.m.)
Indexed	1 year, 2 months ago (May 29, 2024, 10:50 p.m.)
Issued	41 years, 6 months ago (Feb. 1, 1984)
Published	41 years, 6 months ago (Feb. 1, 1984)
Published Online	41 years, 6 months ago (Feb. 1, 1984)
Published Print	41 years, 6 months ago (Feb. 1, 1984)

Funders 0

None

BibTeX

@article{Birchmeier_1984, title={3’ editing of mRNAs: sequence requirements and involvement of a 60-nucleotide RNA in maturation of histone mRNA precursors.}, volume={81}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.81.4.1057}, DOI={10.1073/pnas.81.4.1057}, number={4}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Birchmeier, C and Schümperli, D and Sconzo, G and Birnstiel, M L}, year={1984}, month=feb, pages={1057–1061} }

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