DOI: 10.1073/pnas.81.2.337. Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.

Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.

10.1073/pnas.81.2.337

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Copper resistance in yeast is controlled by the CUP1 locus. The level of resistance is proportional to the copy number of this locus, which can be found in up to 15 tandemly iterated copies. To elucidate the molecular mechanisms controlling the amplification and expression of the CUP1, locus, we determined its full nucleotide sequence. We have also identified and mapped two transcription units within the basic amplification unit of CUP1 in laboratory yeast strains. One of those transcription units is inducible by copper and encodes a low molecular weight copper binding protein--copper chelatin. The increased production of chelatin, due to both gene amplification and induction of transcription, leads to increased resistance of yeast cells to copper ions.

Bibliography

Karin, M., Najarian, R., Haslinger, A., Valenzuela, P., Welch, J., & Fogel, S. (1984). Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proceedings of the National Academy of Sciences, 81(2), 337â341.

Authors 6

M Karin (first)
R Najarian (additional)
A Haslinger (additional)
P Valenzuela (additional)
J Welch (additional)
S Fogel (additional)

References 0 Referenced 206

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 5:31 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:59 a.m.)
Indexed	2 weeks, 6 days ago (Aug. 5, 2025, 8:50 a.m.)
Issued	41 years, 7 months ago (Jan. 1, 1984)
Published	41 years, 7 months ago (Jan. 1, 1984)
Published Online	41 years, 7 months ago (Jan. 1, 1984)
Published Print	41 years, 7 months ago (Jan. 1, 1984)

Funders 0

None

BibTeX

@article{Karin_1984, title={Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast.}, volume={81}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.81.2.337}, DOI={10.1073/pnas.81.2.337}, number={2}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Karin, M and Najarian, R and Haslinger, A and Valenzuela, P and Welch, J and Fogel, S}, year={1984}, month=jan, pages={337–341} }

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