DOI: 10.1073/pnas.81.13.4178. Detection of an Epstein-Barr virus-associated membrane antigen in Epstein-Barr virus-transformed nonproducer cells by leukocyte migration inhibition and blocking antibody.

Detection of an Epstein-Barr virus-associated membrane antigen in Epstein-Barr virus-transformed nonproducer cells by leukocyte migration inhibition and blocking antibody.

10.1073/pnas.81.13.4178

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

Soluble membrane fractions derived from Raji cells trigger lymphocytes of Epstein-Barr virus (EBV)-seropositive, but not EBV-seronegative, individuals to release a lymphokine that inhibits leukocyte migration. The reaction can be blocked by the sera of patients with EBV-DNA-carrying tumors, Burkitt lymphoma, or nasopharyngeal carcinoma. Absorption of these sera with EBV-positive, but not EBV-negative, cells abrogates their blocking activity. These findings suggest that the antigen responsible for the leukocyte migration inhibition reaction is an EBV-encoded or an EBV-induced membrane component. The antigen is not identical with EBV-associated nuclear antigen or any other known antibody-detected EBV antigen.

Bibliography

Szigeti, R., Sulitzeanu, D., Henle, G., Henle, W., & Klein, G. (1984). Detection of an Epstein-Barr virus-associated membrane antigen in Epstein-Barr virus-transformed nonproducer cells by leukocyte migration inhibition and blocking antibody. Proceedings of the National Academy of Sciences, 81(13), 4178â4182.

Authors 5

R Szigeti (first)
D Sulitzeanu (additional)
G Henle (additional)
W Henle (additional)
G Klein (additional)

References 0 Referenced 17

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 5:26 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:56 a.m.)
Indexed	1 year, 10 months ago (Oct. 22, 2023, 9:30 a.m.)
Issued	41 years, 2 months ago (July 1, 1984)
Published	41 years, 2 months ago (July 1, 1984)
Published Online	41 years, 2 months ago (July 1, 1984)
Published Print	41 years, 2 months ago (July 1, 1984)

Funders 0

None

BibTeX

@article{Szigeti_1984, title={Detection of an Epstein-Barr virus-associated membrane antigen in Epstein-Barr virus-transformed nonproducer cells by leukocyte migration inhibition and blocking antibody.}, volume={81}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.81.13.4178}, DOI={10.1073/pnas.81.13.4178}, number={13}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Szigeti, R and Sulitzeanu, D and Henle, G and Henle, W and Klein, G}, year={1984}, month=jul, pages={4178–4182} }

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