DOI: 10.1073/pnas.80.8.2127. Nucleotide sequence of the human parathyroid hormone gene.

Nucleotide sequence of the human parathyroid hormone gene.

10.1073/pnas.80.8.2127

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

From a lambda phage gene library we have isolated phage containing the gene encoding human preproparathyroid hormone. The phage were isolated by using both the plaque-hybridization technique and the in vivo recombination-selection technique. The human preproparathyroid hormone gene contains two intervening sequences that separate the gene into a 5' noncoding domain, a "prepro" sequence domain, and a domain containing the parathyroid hormone sequence and the 3' noncoding region. The gene is approximately 4,200 base pairs long. Restriction endonuclease analysis of human leukocyte DNA shows that the haploid human genome contains one copy of the preproparathyroid hormone gene. A 14-base-pair sequence of alternating purines and pyrimidines that has the potential of adopting the Z-DNA conformation lies 134 base pairs upstream from the presumed site of initiation of transcription.

Bibliography

Vasicek, T. J., McDevitt, B. E., Freeman, M. W., Fennick, B. J., Hendy, G. N., Potts, J. T., Rich, A., & Kronenberg, H. M. (1983). Nucleotide sequence of the human parathyroid hormone gene. Proceedings of the National Academy of Sciences, 80(8), 2127â2131.

Authors 8

T J Vasicek (first)
B E McDevitt (additional)
M W Freeman (additional)
B J Fennick (additional)
G N Hendy (additional)
J T Potts (additional)
A Rich (additional)
H M Kronenberg (additional)

References 0 Referenced 130

None

Dates

Type	When
Created	19 years, 3 months ago (May 31, 2006, 5:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:52 a.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 7:23 a.m.)
Issued	42 years, 4 months ago (April 1, 1983)
Published	42 years, 4 months ago (April 1, 1983)
Published Online	42 years, 4 months ago (April 1, 1983)
Published Print	42 years, 4 months ago (April 1, 1983)

Funders 0

None

BibTeX

@article{Vasicek_1983, title={Nucleotide sequence of the human parathyroid hormone gene.}, volume={80}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.80.8.2127}, DOI={10.1073/pnas.80.8.2127}, number={8}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Vasicek, T J and McDevitt, B E and Freeman, M W and Fennick, B J and Hendy, G N and Potts, J T and Rich, A and Kronenberg, H M}, year={1983}, month=apr, pages={2127–2131} }

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