DOI: 10.1073/pnas.80.20.6229. Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.

Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.

10.1073/pnas.80.20.6229

Crossref journal-article

Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences (341)

Abstract

The nucleotide sequence of v-rel, the oncogene carried by reticuloendotheliosis virus (REV), has been determined. The defective transforming genome REV arose through the insertion of v-rel (1,415 nucleotides) into the env gene of the helper virus REV-A. The predicted rel protein (503 amino acids) employs the REV-A env initiator and terminates within the p20E region of env. Because there are no natural antisera that detect the REV transforming protein, this nucleotide sequence provides the first step toward its isolation and characterization. The predicted protein is clearly distinct from all other reported transforming proteins but may be very distantly related to members of the src family.

Bibliography

Stephens, R. M., Rice, N. R., Hiebsch, R. R., Bose, H. R., & Gilden, R. V. (1983). Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus. Proceedings of the National Academy of Sciences, 80(20), 6229â6233.

Authors 5

R M Stephens (first)
N R Rice (additional)
R R Hiebsch (additional)
H R Bose (additional)
R V Gilden (additional)

References 0 Referenced 96

None

Dates

Type	When
Created	19 years, 2 months ago (May 31, 2006, 3:21 a.m.)
Deposited	3 years, 4 months ago (April 13, 2022, 11:53 a.m.)
Indexed	3 weeks, 3 days ago (Aug. 5, 2025, 8:54 a.m.)
Issued	41 years, 10 months ago (Oct. 1, 1983)
Published	41 years, 10 months ago (Oct. 1, 1983)
Published Online	41 years, 10 months ago (Oct. 1, 1983)
Published Print	41 years, 10 months ago (Oct. 1, 1983)

Funders 0

None

BibTeX

@article{Stephens_1983, title={Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus.}, volume={80}, ISSN={1091-6490}, url={http://dx.doi.org/10.1073/pnas.80.20.6229}, DOI={10.1073/pnas.80.20.6229}, number={20}, journal={Proceedings of the National Academy of Sciences}, publisher={Proceedings of the National Academy of Sciences}, author={Stephens, R M and Rice, N R and Hiebsch, R R and Bose, H R and Gilden, R V}, year={1983}, month=oct, pages={6229–6233} }

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